Arizona Cardinals vs Seattle Seahawks: Preview Prediction

Oct 17, 2016; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) avoids the tackle attempt of New York Giants cornerback Buster Skrine (41) as he scores a first quarter touchdown at University of Phoenix Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports
Oct 17, 2016; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) avoids the tackle attempt of New York Giants cornerback Buster Skrine (41) as he scores a first quarter touchdown at University of Phoenix Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports /
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Oct 17, 2016; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) avoids the tackle attempt of New York Giants cornerback Buster Skrine (41) as he scores a first quarter touchdown at University of Phoenix Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports
Oct 17, 2016; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) avoids the tackle attempt of New York Giants cornerback Buster Skrine (41) as he scores a first quarter touchdown at University of Phoenix Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports /

Keys to victory, Offense:

Quarterback Carson Palmer injured his hamstring in Monday’s win over the Jets, and was barely practiced all week. While he is listed as questionable, Palmer is expected to play without any limitation according to Bruce Arians.

Palmer may end up having to bear the offensive load as the Seahawks boast the league’s third best run defense. While David Johnson is expected to receive a lot of carries, he may have a tough time finding gaps against a front seven featuring Michael Bennett and Kam Chancellor. A majority of his contribution may end up coming through the air.

On the injury side, Mike Iupati will return to the offensive line after missing last week’s game with an ankle injury. Jaron Brown practiced in a limited fashion on Friday and is listed as questionable. John Brown is listed as doubtful after a blood test revealed he carries the sickle-cell trait.

With the possibility of being shorthanded two receivers, Larry Fitzgerald and the rest of the receiving corp will have to put in the extra effort to create separation.  Michael Floyd has had big games against the Seahawks in the past, and figures to play a huge part in the passing game.