Cardinals Game Sunday: Cardinals vs. Rams odds and prediction for Week 4 NFL game

(Photo by Kirby Lee-USA TODAY Sports) Kyler Murray
(Photo by Kirby Lee-USA TODAY Sports) Kyler Murray /

Four weeks into the 2021 season and the 3-0 Arizona Cardinals have found themselves in a huge Week 4 matchup against 3-0 Los Angeles Rams.

Heading into their first NFC West matchup of the season against the Los Angeles Rams, the Arizona Cardinals have yet to lose a game this year. The Cardinals are 3-0 for the first time since 2015 and with a win over the Rams this weekend, Arizona could be sitting with a 4-0 record for just the second time since 1974.

The Cardinals have a tough task in front of them though if they’re going to remain undefeated. Los Angeles is also 3-0 this season and they just handed the defending Super Bowl champion Tampa Bay Buccaneers a 10-point loss in Week 3.

Arizona Cardinals vs. Los Angeles Rams odds Week 4

Point Spread:

  • Cardinals +4.5 (-110)
  • Rams -4.5 (-110)


  • Cardinals +180
  • Rams -225


  • 55.0 points
    • Over  -105
    • Under -115

(Odds via WynnBet)

Arizona Cardinals vs. Los Angeles Rams prediction Week 4

Since Sean McVay became the head coach of the Rams in 2017, they have never lost a matchup with the Cardinals. Los Angeles has come away with a victory in each of their last eight meetings with Arizona.

If this weekend’s game was taking place in the desert, then the Cardinals would likely have a better chance at ending their losing streak to the Rams. But with the matchup happening inside Los Angeles’ SoFi Stadium in addition to crowd noise becoming a factor for visiting teams once again this season, it’s going to be hard for Arizona to remain unbeaten after this weekend.

Expect Sunday’s game to be close between these two NFC West rivals. But the Rams are just playing too well on both sides of the ball so far this season to suffer a loss on their home field to the Cardinals this week.

Prediction: Rams win

WynnBET Promo: Bet $1, Win $100 if any NFL or college football team scores. Claim offer now.

Must Read. 5 takeaways from Cardinals win in Week 3. light