Cardinals Game Sunday: Cardinals vs. 49ers odds and prediction for Week 5 NFL game

(Photo by (Photo by Christian Petersen/Getty Images) Jordan Hicks
(Photo by (Photo by Christian Petersen/Getty Images) Jordan Hicks /

Coming off a huge divisional win last week, the Arizona Cardinals and their 4-0 record will face another NFC West opponent in Week 5, the San Francisco 49ers.

After the first four games of the 2021 season, the Arizona Cardinals are the only team left with an undefeated record in the entire league. Just like everyone predicted.

Yes, the Cardinals at 4-0 are the only team without a loss in the NFL this year. It wasn’t an easy achievement though. Arizona went out on the road last week and took down the mighty Los Angeles Rams, who were also unbeaten prior to the matchup.

The Cardinals‘ win over the Rams sent a statement to the rest of the league. Arizona is for real this season and defeating them is no longer going to be simple like it was a few years ago.

Arizona Cardinals vs. San Francisco 49ers odds Week 5

Point Spread:

  • Cardinals -5.5 (-110)
  • 49ers +5.5 (-110)


  • Cardinals -245
  • 49ers +205


  • 50.5 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. San Francisco 49ers prediction Week 5

Even though they looked impressive against Los Angeles last week, Arizona has to be careful to not assume that their upcoming matchup against the 2-2 San Franciso 49ers will wind up resulting in another victory.

Divisional games are typically closer than the rest of the matchups on a team’s schedule and this should be the case for the 49ers and Cardinals next weekend.

Still, Arizona should still be able to get the job done and come away with a win. Especially since there is a chance that San Francisco will be starting a rookie quarterback under center.

Prediction: Cardinals win

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