Cardinals Game Today: Cardinals vs. 49ers injury report, spread, over/under, schedule, live stream, TV channel

(Photo by Michael Zagaris/San Francisco 49ers/Getty Images) Kyler Murray
(Photo by Michael Zagaris/San Francisco 49ers/Getty Images) Kyler Murray /

After a big win over the Los Angeles Rams, can the Arizona Cardinals remain unbeaten when they take on the San Francisco 49ers?

Four games into the 2021 season, the Arizona Cardinals are the lone team sitting atop the NFC West. The Cardinals and their 4-0 record will take on a divisional opponent for the second week in a row when they go up against the San Francisco 49ers inside State Farm Stadium.

Arizona Cardinals injury report vs. San Francisco 49ers Week 5


  • Byron Murphy Jr. (CB) – OUT
  • Justin Murray (OL) – OUT
  • Kelvin Beachum (RT) – Questionable
  • Chase Edmonds (RB) – Questionable
  • Antonio Hamilton (CB) – Questionable
  • Maxx Williams (TE) – Questionable
  • Eno Benjamin (RB) – Questionable
  • Marco Wilson (CB) – Questionable


  • Jimmy Garoppolo (QB) – OUT
  • George Kittle (TE) – OUT
  • K’Waun Williams (CB) – OUT
  • Samson Ebukam (DL) – Questionable
  • Javon Kinlaw (DT) – Questionable

Arizona Cardinals vs. San Francisco 49ers Odds, Spread, Over/Under & Betting Pick for Week 5

Odds courtesy of WynnBet.

Point Spread:

  • Cardinals -5.5 (-110)
  • 49ers +5.5 (-110)


  • Cardinals -240
  • 49ers +200


  • 49.0 points
    • Over -110
    • Under -110

Betting Pick:

Three of the last four times the Cardinals have taken on the 49ers in Arizona, the game has been decided by a total of three points. The Cardinals should come out on top in Sunday’s matchup, but it might be a good idea to take them with the moneyline instead of betting on the point spread.

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What channel is the Arizona Cardinals game on in Week 5?

Sunday’s NFC West showdown between the Cardinals and 49ers will air on FOX with Kevin Kugler and Mark Sanchez calling the action in the broadcast booth.

Arizona Cardinals vs. San Franciso 49ers live stream

For those in search of a streaming option for Sunday’s matchup, fuboTV is a solid option to consider. The streaming service offers Cloud DVR, local channels in most markets, no cancellation fees, and for new users, they are currently offering a free trial for seven days.

Arizona Cardinals next game and schedule

After taking on San Francisco on Sunday, Arizona will head out on the road for a tough battle against the Cleveland Browns in Week 6.

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