Cardinals Game Sunday: Cardinals vs. Browns odds and prediction for Week 6 NFL game

(Photo by Kirby Lee-USA TODAY Sports) Budda Baker
(Photo by Kirby Lee-USA TODAY Sports) Budda Baker /

In a tough road matchup against the Cleveland Browns next Sunday, the Arizona Cardinals will look to improve their record for the 2021 season to 6-0.

Last week’s win over the San Francisco 49ers turned out to be a classic NFC West battle for the Arizona Cardinals. But the Cardinals came out of the matchup with the victory and they are still the only team left in the NFL that has yet to lose a game this season.

In Week 6, Arizona will take their undefeated record on the road to face a Cleveland Browns team that has won three of their last four games.

Arizona Cardinals vs. Cleveland Browns odds Week 6

Point Spread:

  • Cardinals +2.5 (-105)
  • Browns -2.5 (-115)


  • Cardinals +125
  • Browns -145


  • 50.0 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. Cleveland Browns prediction Week 6

Cleveland is coming off a battle of their own against the Los Angeles Chargers, but their Week 5 matchup resulted in a loss, unlike Arizona’s. Still, the Browns of 2021 are not the same lovable losers that they’ve been for the majority of the 21st century.

Under head coach Kevin Stefanski, Cleveland has quickly established themselves as a contender in the AFC. The Browns made it to the divisional round of the playoffs last season and they’re on track to make the postseason again this year.

The matchup to watch next Sunday will be Cleveland’s rushing attack against the Cardinals’ run defense. The Browns are the best in the NFL this season in just about every rushing category while Arizona’s defense is giving up the second-most rushing yards per carry in the league this year.

Containing Cleveland’s two-headed monster in their offensive backfield will absolutely be the key to the Cardinals extending their win streak to six games this week.

Prediction: Cardinals win

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