Cardinals Game Sunday: Cardinals vs. Lions odds and prediction for Week 15 NFL game

(Photo by Mark J. Rebilas-USA TODAY Sports) Christian Kirk
(Photo by Mark J. Rebilas-USA TODAY Sports) Christian Kirk /

Following a tough loss to the Los Angeles Rams in Week 14, the Arizona Cardinals will attempt to get back on track this weekend in a road matchup against the Detroit Lions.

Since they last played on a Monday, the Arizona Cardinals have slightly less time to prepare for their next game than they typically do. Luckily for the Cardinals, their shortened week of preparation will lead to a matchup against the 1-11-1 Detroit Lions on Sunday.

Arizona Cardinals vs. Detroit Lions odds Week 15

Point Spread:

  • Cardinals -12.0 (-110)
  • Lions +12.0 (-110)


  • Cardinals -700
  • Lions +500


  • 47.5 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. Detroit Lions prediction Week 15

Sunday will be the third time this season that the Cardinals head into a game in which they are favored by at least 10 points. Earlier this year, Arizona was favored by 18 points in their Week 7 win over the Houston Texans and they were favored by 10.5 points in their Week 10 loss to the Carolina Panthers.

However, both of those games took place inside the Cardinals‘ home stadium. This weekend’s matchup in Detroit will be the first time since Week 15 of the 2009 season that Arizona is heading into a road game where they are favored to win by at least 10 points.

Coincidentally, the Cardinals’ opponent in that Week 15 matchup in 2009 was the Lions. Arizona went on to win that game in Detroit and they should be able to come out on top against the Lions this weekend as well.

Prediction: Cardinals win

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