Cardinals Game Saturday: Cardinals vs. Colts odds and prediction for Week 16 NFL game

(Photo by Christian Petersen/Getty Images)
(Photo by Christian Petersen/Getty Images) /

If the Arizona Cardinals are going to have any hope at still getting the top seed in the NFC this year, they need a win over the Indianapolis Colts on Saturday.

For the first time this season, the Arizona Cardinals are in the middle of a multi-game losing streak. The Cardinals will have an opportunity to get a win for the first time since Week 13 when they host the Indianapolis Colts in a Christmas night showdown on Saturday.

Will Arizona be able to get their first victory inside State Farm Stadium since Week 7 or will they leave the field on Saturday with another loss added to their record?

Arizona Cardinals vs. Indianapolis Colts odds Week 16

Point Spread:

  • Cardinals -1.0 (-110)
  • Colts +1.0 (-110)


  • Cardinals -120
  • Colts +100


  • 49.0 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. Indianapolis Colts prediction Week 16

Arizona’s opponent this week is no slouch, hence the reason why the Cardinals are only favored by a point on their home field.

After a 1-4 start to the season, the Colts have won seven of their last nine matchups, including a 10-point victory over the New England Patriots last week. This year, Indianapolis has an offense that ranks third in scoring and a defense that ranks ninth in points allowed.

Arizona’s back seems to be against the wall this week and everything appears to be pointing to them suffering a loss to the Colts on Saturday. However, the Cardinals will get back to what got them off to such a hot start earlier this season and that is running the ball.

Stopping the run has shown to be a weakness of the Indianapolis defense at times this year (22nd in rushing yards allowed per carry) and Arizona will use this to their advantage by having James Conner, Chase Edmonds, and Kyler Murray run it down their opponent’s throats.

Prediction: Cardinals win

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