Cardinals Game Sunday: Cardinals vs. Seahawks odds and prediction for Week 18 NFL game

(Photo by Norm Hall/Getty Images)
(Photo by Norm Hall/Getty Images) /

With a win over the Seattle Seahawks and a little bit of help, the Arizona Cardinals could end up as the champions of the NFC West on Sunday.

During the first-ever Week 18 in NFL history, the Arizona Cardinals will be concluding their 2021 regular season with a divisional matchup against the Seattle Seahawks inside State Farm Stadium.

The Cardinals have already clinched a spot in the 2021 playoffs, but they can capture the NFC West title on Sunday if they get a win over the Seahawks and the Los Angeles Rams lose to the San Francisco 49ers.

Arizona Cardinals vs. Seattle Seahawks odds Week 18

Point Spread:

  • Cardinals -6.5 (-100)
  • Seahawks +6.5 (-120)


  • Cardinals -280
  • Seahawks +225


  • 48.0 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. Seattle Seahawks prediction Week 18

Earlier this season, Arizona was able to go into Seattle’s home building and leave the field with a 10-point victory over the Seahawks. The Cardinals were even able to do this without quarterback Kyler Murray in the lineup.

This weekend, Arizona should be able to get another win and complete a regular-season sweep of Seattle for the first time since 2009.

Before hanging 51 points on the Detroit Lions last week, the Seahawks have struggled mightily during the 2021 season. Seattle is currently sitting with a 6-10 record, even if they get a victory on Sunday, they will end the 2021 campaign with a last-place finish in their division for the first time since 1996 when they were actually part of the AFC West.

Despite the Seahawks‘ struggles this season, a win for the Cardinals is no guarantee either, especially since it will be played on Arizona’s home field. The Cardinals are 3-4 inside State Farm Stadium during the 2021 campaign and they haven’t earned a victory at home since Week 7 against the Houston Texans.

However, Arizona has more to gain from a win on Sunday than Seattle, so we should still be expecting the Cardinals to add one more victory to their 2021 record.

Prediction: Cardinals win

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