Cardinals Game Sunday: Cardinals vs. Panthers odds and prediction for Week 10 NFL game

(Photo by Christian Petersen/Getty Images) Zach Ertz
(Photo by Christian Petersen/Getty Images) Zach Ertz /

Will the Arizona Cardinals be able to continue their red-hot start to the 2021 season with another win on Sunday when they face the Carolina Panthers?

Against the San Francisco 49ers last week, the Arizona Cardinals were presented with the task of getting a win without quarterback Kyler Murray or wide receiver DeAndre Hopkins. The Cardinals not only accomplished that task, but they exceeded just about all of their expectations on their way to a 14-point victory over the 49ers.

This week against the Carolina Panthers, Murray and Hopkins could still be sidelined. However, Arizona‘s opponent on Sunday is expected to be much easier than San Francisco.

Arizona Cardinals vs. Carolina Panthers odds Week 10

Point Spread:

  • Cardinals -10 (-110)
  • Panthers +10 (-110)


  • Cardinals -480
  • Panthers +380


  • 44.0 points
    • Over  -110
    • Under -110

(Odds via WynnBet)

Arizona Cardinals vs. Carolina Panthers prediction Week 10

During their win over the 49ers last weekend, the Cardinals proved that they have enough depth and talent on their roster to win without Murray and Hopkins in the lineup.

It seems like there’s a good chance that Arizona will have to do that again when they welcome the Panthers to State Farm Stadium on Sunday.

Carolina is expected to have P.J. Walker out on the field as their starting signal-caller following the recent injury to Sam Darnold. Walker does have the potential to cause a few problems for the Cardinals, but it would be incredibly shocking if Arizona was unable to leave the field this weekend with a win.

Prediction: Cardinals win

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