HC Jonathan Gannon may not be the only notable Cardinal out the door

Could Kyler Murray be gone as well?
Arizona Cardinals quarterback Kyler Murray watches his team from the sidelines as they play the San Francisco 49ers at State Farm Stadium in Glendale on Nov. 16, 2025.
Arizona Cardinals quarterback Kyler Murray watches his team from the sidelines as they play the San Francisco 49ers at State Farm Stadium in Glendale on Nov. 16, 2025. | Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images

The Cardinals parted ways with head coach Jonathan Gannon on Monday morning after the team finished a dismal 3–14. However, it isn’t an understatement to say that Gannon isn’t the only notable member out the door.

Arizona opted to retain general manager Monti Ossenfort in 2026, enabling him to pull the trigger on any moves he believes would be worthwhile going forward. Hired in 2023, Ossenfort has made plenty of decisions regarding the team’s roster, but he may be facing his biggest decision yet.

To think the firing of Gannon wasn’t the biggest decision he made, Ossenfort is lined up to determine the future at the quarterback position. After the way 2025 panned out, he may be inclined to make a bombshell move that won’t just impact the Cardinals or the NFC West, but the entire NFL.

Could the Cardinals move on from Kyler Murray?

Murray only played in five games in 2025 after undergoing a foot injury in Week 5 that would end up sidelining him for the remainder of the season. But the truth is that it is not far-fetched to think that the 28-year-old just flat out lost his job as the team’s starter.

MORE: The Jonathan Gannon era finally ends as Cardinals' 2025 season was an utter disaster

Heading into the Cardinals’ Week 9 matchup, Murray was a limited participant all week long, lining him up to be good to go by Week 10 at the latest. However, Murray would then be placed on injured reserve out of nowhere, raising questions about why he was limited to begin with.

Gannon announced in December that Murray would not play any more games in 2025, allowing backup Jacoby Brissett to start the remainder of the season.

While a flashy, dual-threat quarterback, Murray’s numbers in the time he saw were not great. He completed 68% of his passes, but the offense wasn’t fluent by any means. Meanwhile, with Brissett, the offense looked much cleaner, as he was able to find his pass catchers downfield more often. Overall, the growing speculation is that Murray lost his job to Brissett.

In 2026, Murray is guaranteed $36.8 million, part of the five-year, $230 million contract he signed in 2022.

However, Ossenfort wasn’t the one to draft Murray, which raises questions about whether the seven-year quarterback will remain a Cardinal in 2026.

With Ossenfort and upper management already moving on from Gannon, perhaps more change will be coming, and perhaps a massive roster overhaul.

It will be interesting to see what the Cardinals have in mind regarding the quarterback position, and it won’t be a surprise if the firing of Gannon was the first of many dominoes to fall.

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